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The portal vein or hepatic portal vein is a blood vessel that carries blood from the gastrointestinal tract, gallbladder, pancreas and spleen to the liver This blood contains nutrients and toxins extracted from digested contents Approximately 75% of total liver blood flow is through the portal vein, with the remainder coming from the hepatic artery proper The blood leaves the liver to the heart in the hepatic veins The portal vein is not a true vein Key Terms sinusoid Any of several channels through which venous blood passes in various organs; The hepatic artery is a branch of the coeliac trunk and provides 25% of blood to the liver The portal vein, formed by the mesenteric and the splenic veins, supplies 75% of the blood to the liver Firstly, oxygen is delivered to the liver from both of these arteries Approximately 50% of oxygen demand is met by the portal vein and 50% by the Liver Histology Gastrointestinal Medbullets Step 1 Hepatic portal vein labeled